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Agilent Technologies, Human Metabolome Technologies Collaborate on Metabolomics Solution to Speed Disease and Drug Research; Agilent's Instrument Technology, HMT's Biochemical Expertise Combine to Help Scientists Map Human Metabolome

June 19, 2005

TOKYO--(BUSINESS WIRE)--June 20, 2005--Agilent Technologies Inc. (NYSE:A) and Human Metabolome Technologies, a Japanese bioventure, today announced they have signed an agreement to collaborate on an integrated set of metabolome analysis tools designed to help researchers discover potential therapeutics.

Under the agreement, the two companies will work to integrate HMT's novel biochemical assays with Agilent's capillary electrophoresis (CE) and mass spectrometry (MS) technologies for the profiling, identification and quantitation of metabolic markers. Metabolomics, which aims to characterize the complete set of metabolites, provides critical insights into how living things function under particular conditions, such as stress or disease, and may help identify targets for drug development. Typical human cells contain thousands of metabolites, and the aim of the HMT/Agilent solution is to develop a new and unique mass-spectrometry-based workflow for high throughput analysis.

"The human metabolome is the next frontier of research beyond the genome and the proteome, and metabolomics promises exciting advances," said Dr. Yoshihiro Ohtaki, president of HMT. "The combination of Agilent's robust and sensitive CE/MS technology with our latest metabolomics methodologies will speed the identification of metabolites and improve scientists' ability to map the human metabolome."

The Agilent and HMT metabolomics solution is expected to be on the market within six months.

"Metabolomics is a rapidly emerging and promising area in life science research and an area of focus for Agilent," said Taia Ergueta, Agilent business manager for proteomics, Life Sciences and Chemical Analysis group. "We offer competencies in gene expression, separation technologies, mass spectrometry and informatics. The further application of HMT's expertise in metabolomics methodologies will speed the development of new tools for metabolomics research."

Agilent and HMT are participating in the First International Conference of the Metabolomics Society in Tsuruoka City, Japan, today through June 23.

About Human Metabolome Technologies

Human Metabolome Technologies Inc. (HMT) was founded in July 2003 based on Capillary Electrophoresis-Mass Spectrometry (CE-MS) technologies that were developed by Masaru Tomita (Director of the Institute for Advanced Biosciences, Keio University) and Tomoyoshi Soga (Associate Professor of Institute for Advanced Biosciences, Keio University). HMT technologies make it possible to measure over 1,600 metabolites in cells and organisms simultaneously and comprehensively, at high speed and with high resolution. HMT provides corporate partners with data of the metabolome measured by CE-MS and technical tools, which in turn help them develop products effectively, i.e., pharmaceuticals, functional foods and fermentation processes. HMT has already begun collaborations with several pharmaceutical and food companies for biomarker studies. Information about HMT is available on the Web at www.humanmetabolome.com.

About Agilent Integrated Biology Solutions

Agilent IBS is a leading supplier of life science research systems that enable scientists to understand complex biological processes, determine disease mechanisms and speed drug discovery. Engineered for sensitivity, reproducibility and workflow productivity, Agilent's integrated biology solutions include instrumentation, microfluidics, software, microarrays, consumables and services for genomics, proteomics and metabolomics applications.

About Agilent Technologies

Agilent Technologies Inc. (NYSE:A) is the world's premier measurement company and a technology leader in communications, electronics, life sciences and chemical analysis. The company's 28,000 employees serve customers in more than 110 countries. Agilent had net revenue of $7.2 billion in fiscal year 2004. Information about Agilent is available on the Web at www.agilent.com.

Forward-Looking Statements

This news release contains forward-looking statements as defined in the Securities Exchange Act of 1934 and is subject to the safe harbors created therein. The forward-looking statements contained herein include, but are not limited to, information regarding the timetable for making the Agilent/HMT metabolomics solution available to the market and the growth of the market for metabolomics solutions. Such information involves risks and uncertainties that could cause Agilent's results to differ materially from management's current expectations. Such risks and uncertainties include, but are not limited to the rapid development of life sciences technology and fluctuations in demand for life sciences products.

In addition, other risks that Agilent faces in running its operations include the ability to execute successfully through business cycles while it continues to implement cost reductions; the ability to meet and achieve the benefits of its cost-reduction goals and otherwise successfully adapt its cost structures to continuing changes in business conditions; ongoing competitive, pricing and gross margin pressures; the risk that our cost-cutting initiatives will impair our ability to develop products and remain competitive and to operate effectively; the impact of geopolitical uncertainties on our markets and our ability to conduct business; the ability to improve asset performance to adapt to changes in demand; the ability to successfully introduce new products at the right time, price and mix and other risks detailed in Agilent's filings with the Securities and Exchange Commission, including our Annual Report on Form 10-K for the year ended Oct. 31, 2004, and our Quarterly Report on Form 10-Q for the period ended April 30, 2005. Forward-looking statements are based on the belief and assumptions of Agilent's management and on currently available information. Agilent undertakes no responsibility to publicly update or revise any forward-looking statement.

NOTE TO EDITORS: Further technology, corporate citizenship and executive news is available on the Agilent news site at www.agilent.com/go/news.

    CONTACT: Agilent
             Sui-Ching Low, +65 6215 4463
             sui-ching_low@agilent.com
             Stuart Matlow, 408-553-7191
             stuart_matlow@agilent.com
              or
             Human Metabolome Technologies
             Mineo Morohashi, busdev@humanmetabolome.com

    SOURCE: Agilent Technologies Inc.